Question 1

How does entropy drive protein-DNA complex formations?

Accepted Answer

Entropy is often increased by ...

Question 2

Explain the expression of the Drosophila even-skipped gene.

Accepted Answer

Expression of the Drosophila even-skipped gene occurs in a series of seven stripes along the axis of the embryo, where each stripe has a separate set of regulatory controls. The eve stripe 2 enhancer region contains cis-acting sites for four different transcription factors that function together to restrict expression of the even structural gene to a small number of cells.

Question 3

What is a result of histone acetylation?

Accepted Answer

A)   repression of transcription
B)   increased transcriptional activity
C)   no effect
D)   remodeling of histone

Question 4

α\alphaα -Helices are usually found in DNA binding proteins because they

Accepted Answer

A)   are the only secondary feature found in proteins.
B)   are the only stable secondary feature in proteins.
C)   have the appropriate diameter to fit into the major groove of DNA.
D)   have the appropriate diameter to fit into the minor groove of DNA.

Question 5

Which of the following best describes when a pattern of gene expression is altered without change in the DNA sequence?

Accepted Answer

A)   epigenetic states
B)   negative autoregulation
C)   positive autoregulation
D)   meiosis

Question 6

The role of the CI protein in the lysogenic pathway is that the

Accepted Answer

A)   lysogenic pathway is favored when CI binds.
B)   lytic pathway is favored when CI binds.
C)   CI protein activates the PR promoter.
D)   CI protein inhibits the PRM promoter.

Question 7

The proteins encoded by GAL1, GAL2, GAL7, and GAL10 are all needed for converting __________ to glucose-6-phosphate.

Accepted Answer

A)   glucose
B)   fructose
C)   galiactose
D)   galactose

Question 8

Explain how transcription of the yeast PHO5 gene is regulated.

Accepted Answer

Transcription of the yeast PHO5 gene is ...

Question 9

Differentiate among the helix-turn-helix, zinc-finger DNA-binding, leucine zipper, and helix-loop-helix motifs.

Accepted Answer

Helix-turn-helix is approximately 20 amino acids long and consists of two $\alpha$-helices connected by a short turn. Zinc-finger motif is approximately 30 amino acids long and coordinates on a zinc atom with two cysteine and two histidine residues. The leucine zipper leucine amino acids are found approximately every seven amino acids, which allows interactions between similarly spaced leucines on the other protein subunit, creating a coiled-coiled structure.
Helix-loop-helix proteins are characterized by a loop region between the DNA binding on
$\alpha$-helix and the dimerization $\alpha$-helix.

Question 10

Differentiate between where bromodomains and chromodomains bind.

Accepted Answer

Bromodomain-containing complex...

Question 11

When bacteriophage  λ\lambdaλ  integrates into the E. coli genome, what is that lifestyle called?

Accepted Answer

A)   lysis
B)   lysogeny
C)   lyophilize
D)   lysine

Question 12

iPS cells can be defined as cells.

Accepted Answer

A)   differentiated
B)   dedifferentiated
C)   embryonic stem
D)   somatic stem

Question 13

A regulon can best be described as units of DNA containing gene(s)  under control of promotor(s) .

Accepted Answer

A)   one; one
B)   multiple; one
C)   multiple; multiple
D)   one; multiple

Question 14

A helix-turn-helix motif can best be described as a(n)  followed by a(n)  .

Accepted Answer

A)   " α\alphaα -helix;  β\betaβ -helix"
B)   " α\alphaα -helix;  α\alphaα -helix"
C)   " β\betaβ -helix;  β\betaβ -helix"
D)   " β\betaβ -helix;  α\alphaα -helix"  B

Question 15

The control point for most gene regulation occurs at the initiation of

Accepted Answer

A)   transcription.
B)   RNA processing.
C)   protein synthesis.
D)   protein modifications.

Question 16

Describe the three broad classes of nucleosome modifications.

Accepted Answer

(1) Histones in nucleosomes undergo a wi...

Question 17

How can the lac promoter and IPTG be used to produce large amounts of a specific protein?

Accepted Answer

As shown in Figure 23.16, the lac promot...

Question 18

Which amino acid residues on histones are acetylated?

Accepted Answer

A)   histidine
B)   lysine
C)   arginine
D)   serine

Question 19

When LexA is autocleaved by RecA*, the SOS genes

Accepted Answer

A)   are repressed.
B)   are activated.
C)   are unaffected.
D)   produce operons.

Question 20

How can pluripotency be induced?

Accepted Answer

Reprogramming of differentiated cells to...

Exam 23: Gene Regulation

How does entropy drive protein-DNA complex formations?

Correct Answer
verified
Entropy is often increased by ...
View Answer

Explain the expression of the Drosophila even-skipped gene.

What is a result of histone acetylation?

Correct Answer
verified

$\alpha$ -Helices are usually found in DNA binding proteins because they

Correct Answer
verified

Which of the following best describes when a pattern of gene expression is altered without change in the DNA sequence?

Correct Answer
verified

The role of the CI protein in the lysogenic pathway is that the

Correct Answer
verified

The proteins encoded by GAL1, GAL2, GAL7, and GAL10 are all needed for converting __________ to glucose-6-phosphate.

Correct Answer
verified

Explain how transcription of the yeast PHO5 gene is regulated.

Correct Answer
verified
Transcription of the yeast PHO5 gene is ...
View Answer

Differentiate among the helix-turn-helix, zinc-finger DNA-binding, leucine zipper, and helix-loop-helix motifs.

Differentiate between where bromodomains and chromodomains bind.

Correct Answer
verified
Bromodomain-containing complex...
View Answer

When bacteriophage $\lambda$ integrates into the E. coli genome, what is that lifestyle called?

Correct Answer
verified

iPS cells can be defined as cells.

Correct Answer
verified

A regulon can best be described as units of DNA containing gene(s) under control of promotor(s) .

Correct Answer
verified

A helix-turn-helix motif can best be described as a(n) followed by a(n) .

Correct Answer
verified
B

The control point for most gene regulation occurs at the initiation of

Correct Answer
verified

Describe the three broad classes of nucleosome modifications.

Correct Answer
verified
(1) Histones in nucleosomes undergo a wi...
View Answer

How can the lac promoter and IPTG be used to produce large amounts of a specific protein?

Correct Answer
verified
As shown in Figure 23.16, the lac promot...
View Answer

Which amino acid residues on histones are acetylated?

Correct Answer
verified

When LexA is autocleaved by RecA*, the SOS genes

Correct Answer
verified

How can pluripotency be induced?

Correct Answer
verified
Reprogramming of differentiated cells to...
View Answer

Exam 23: Gene Regulation

How does entropy drive protein-DNA complex formations?

Correct AnswerverifiedEntropy is often increased by ...View AnswerShow Answer

Explain the expression of the Drosophila even-skipped gene.

What is a result of histone acetylation?

Correct AnswerverifiedShow Answer

α\alphaα -Helices are usually found in DNA binding proteins because they

Correct AnswerverifiedShow Answer

Which of the following best describes when a pattern of gene expression is altered without change in the DNA sequence?

Correct AnswerverifiedShow Answer

The role of the CI protein in the lysogenic pathway is that the

Correct AnswerverifiedShow Answer

The proteins encoded by GAL1, GAL2, GAL7, and GAL10 are all needed for converting __________ to glucose-6-phosphate.

Correct AnswerverifiedShow Answer

Explain how transcription of the yeast PHO5 gene is regulated.

Correct AnswerverifiedTranscription of the yeast PHO5 gene is ...View AnswerShow Answer

Differentiate among the helix-turn-helix, zinc-finger DNA-binding, leucine zipper, and helix-loop-helix motifs.

Differentiate between where bromodomains and chromodomains bind.

Correct AnswerverifiedBromodomain-containing complex...View AnswerShow Answer

When bacteriophage λ\lambdaλ integrates into the E. coli genome, what is that lifestyle called?

Correct AnswerverifiedShow Answer

iPS cells can be defined as cells.

Correct AnswerverifiedShow Answer

A regulon can best be described as units of DNA containing gene(s) under control of promotor(s) .

Correct AnswerverifiedShow Answer

A helix-turn-helix motif can best be described as a(n) followed by a(n) .

Correct AnswerverifiedB

The control point for most gene regulation occurs at the initiation of

Correct AnswerverifiedShow Answer

Describe the three broad classes of nucleosome modifications.

Correct Answerverified(1) Histones in nucleosomes undergo a wi...View AnswerShow Answer

How can the lac promoter and IPTG be used to produce large amounts of a specific protein?

Correct AnswerverifiedAs shown in Figure 23.16, the lac promot...View AnswerShow Answer

Which amino acid residues on histones are acetylated?

Correct AnswerverifiedShow Answer

When LexA is autocleaved by RecA*, the SOS genes

Correct AnswerverifiedShow Answer

How can pluripotency be induced?

Correct AnswerverifiedReprogramming of differentiated cells to...View AnswerShow Answer

Correct Answer
verified
Entropy is often increased by ...
View Answer

Correct Answer
verified

$\alpha$ -Helices are usually found in DNA binding proteins because they

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified
Transcription of the yeast PHO5 gene is ...
View Answer

Correct Answer
verified
Bromodomain-containing complex...
View Answer

When bacteriophage $\lambda$ integrates into the E. coli genome, what is that lifestyle called?

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified
B

Correct Answer
verified

Correct Answer
verified
(1) Histones in nucleosomes undergo a wi...
View Answer

Correct Answer
verified
As shown in Figure 23.16, the lac promot...
View Answer

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified
Reprogramming of differentiated cells to...
View Answer