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Suppose an experimenter becomes proficient with a technique that allows her to move DNA sequences within a prokaryotic genome.If she moves the regulatory gene (lac I) ,along with its promoter,to a position some several thousand base pairs away from its normal position,which would you expect to occur?


A) The repressor will no longer be made.
B) The repressor will no longer bind to the operator.
C) The repressor will no longer bind to the inducer.
D) The lac operon will function normally.

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A type of mutation in bacteria in the repressor results in a molecule known as a super-repressor because it represses the lac operon permanently.Which of the following processes would occur in such a mutant?


A) The repressor protein cannot bind to the operator.
B) A functional repressor protein is produced.
C) The repressor protein cannot bind the inducer.
D) The lac operon will be transcribed continuously.

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Which of the following processes do steroid hormones carry out to produce their effects?


A) They activate key enzymes in metabolic pathways.
B) They activate translation of certain mRNAs.
C) They promote the breakdown of specific mRNAs.
D) They bind to receptors inside the cell and promote transcription of specific genes.

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Which of the following statements correctly describes the role of histone acetylation and DNA methylation in gene regulation?


A) DNA methylation reduces transcription,and histone acetylation promotes transcription.
B) DNA methylation promotes transcription,and histone acetylation reduces transcription.
C) DNA methylation and histone acetylation both promote transcription.
D) DNA methylation and histone acetylation both reduce transcription.

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Since Watson and Crick described the structure of DNA in 1953,which of the following statements might best explain why the function of small RNAs is still being explained?


A) As RNAs have evolved since that time,they have taken on new functions.
B) Watson and Crick described DNA but did not predict any function for RNA.
C) The functions of small RNAs could not be approached until the entire human genome was sequenced.
D) Changes in technology as well as our ability to determine how much of the DNA is expressed have now made this possible.

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Which of the following environments would most likely lead to the transcription of the lactose operon?


A) There is more glucose in the cell than lactose.
B) The cyclic AMP levels are low.
C) There is glucose but no lactose in the cell.
D) The cyclic AMP and lactose levels are both high within the cell.
E) The cAMP level is high and the lactose level is low.

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Transcription factors in eukaryotes usually have DNA-binding domains as well as other domains that are specific for binding other molecules.In general,which of the following would you expect many of them to be able to bind?


A) repressors
B) protein-based hormones
C) other transcription factors
D) tRNA

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One way scientists hope to use the recent knowledge gained about noncoding RNAs lies with the possibilities for their use in medicine.Of the following scenarios for future research,which would you expect to gain most from RNAs?


A) exploring a way to turn on the expression of introns
B) targeting siRNAs to disable the expression of an allele associated with an autosomal recessive disease
C) targeting siRNAs to disable the expression of an allele associated with an autosomal dominant disease
D) creating organisms that can be useful for pharmaceutical drug design

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