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Which of the following statements about cancer is FALSE?


A) Viruses cause some cancers.
B) Tobacco use is responsible for more than 20% of all cancer deaths.
C) A mutation in even a single cancer-critical gene is sufficient to convert a normal cell into a cancer cell.
D) Chemical carcinogens cause cancer by changing the nucleotide sequence of DNA.

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At desmosomes, cadherin molecules are connected to


A) actin filaments.
B) intermediate filaments.
C) microtubules.
D) gap junctions.

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A basal lamina


A) is a thin layer of connective-tissue cells and matrix underlying an epithelium.
B) is a thin layer of extracellular matrix underlying an epithelium.
C) is attached to the apical surface of an epithelium.
D) separates epithelial cells from each other.

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B

Match each protein with the correct label in Figure 20-1. Match each protein with the correct label in Figure 20-1.   Figure 20-1 -fibronectin Figure 20-1 -fibronectin

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A pluripotent cell


A) can only be produced in the laboratory.
B) can give rise to all the tissues and cell types in the body.
C) can only give rise to stem cells.
D) is considered to be terminally differentiated.

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Which of the following molecules is NOT found in plants?


A) cellulose
B) lignin
C) collagen
D) pectin

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Which of the following is NOT an example of a connective tissue?


A) bone
B) the layer of photoreceptors in the eye
C) the jellylike interior of an eye
D) cartilage

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Mouse embryonic stem (ES) cells


A) can only be grown in the laboratory.
B) can give rise to all tissues and cell types in the body except germ cells.
C) can be made in the lab from human iPS cells.
D) come from the inner cell mass of early embryos.

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Cadherins


A) are used to transfer proteins from one cell to another.
B) mediate cell-cell attachments through homophilic interactions.
C) are abundant in the plant cell wall.
D) bind to collagen fibrils.

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B

Fibroblasts organize the collagen of the extracellular matrix by


A) cutting and rejoining the fibrils.
B) processing procollagen into collagen.
C) twisting fibrils together to make ropelike fibers.
D) pulling the collagen into sheets or cables after it has been secreted.

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A certain mutation in the receptor for epidermal growth factor (EGF) causes the mutated receptor protein to send a positive signal along the associated intracellular signaling pathway even when the EGF ligand is not bound to it.This signal leads to abnormal cell proliferation in the absence of growth factor.On the basis of this information, would you class the gene for the EGF receptor as a tumor suppressor gene or a potential oncogene? Explain your answer.

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The mutation described leads toward canc...

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Match each name below with the best depiction of the type of epithelial sheet shown in Figure 20-2.Each name and each picture will only be used once. (A) Match each name below with the best depiction of the type of epithelial sheet shown in Figure 20-2.Each name and each picture will only be used once. (A)    (B)    (C)    (D)    Figure 20-2 -columnar __________ (B) Match each name below with the best depiction of the type of epithelial sheet shown in Figure 20-2.Each name and each picture will only be used once. (A)    (B)    (C)    (D)    Figure 20-2 -columnar __________ (C) Match each name below with the best depiction of the type of epithelial sheet shown in Figure 20-2.Each name and each picture will only be used once. (A)    (B)    (C)    (D)    Figure 20-2 -columnar __________ (D) Match each name below with the best depiction of the type of epithelial sheet shown in Figure 20-2.Each name and each picture will only be used once. (A)    (B)    (C)    (D)    Figure 20-2 -columnar __________ Figure 20-2 -columnar __________

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Rb is a tumor suppressor gene; its normal function is to help restrain cell division.Loss of both copies of Rb is a causative factor in some kinds of cancer.You propose to treat these cancers by injecting the patients with a viral vector that carries a copy of the Rb gene and has the ability to infect all the cells of the body, thereby artificially driving expression of Rb in all the cells, including the cancer cells.But your colleague replies, "No! You'll kill the patient, because you will halt cell division throughout the body." A.Why would halting cell division throughout the body kill a full-grown adult? B.Is your colleague right in thinking that forced expression of Rb in every cell will halt all cell division?

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A.Many vital tissues in the adult body, ...

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Drugs that block the function of oncogenic proteins hold great promise in the fight against cancer.Should cancer researchers also be attempting to design drugs that will interfere with the products of tumor suppressor genes? Explain.

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Oncogenic proteins lead toward cancer, b...

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A major distinction between the connective tissues in an animal and other main tissue types such as epithelium, nervous tissue, or muscle is the


A) ability of connective-tissue cells such as fibroblasts to change shape.
B) amount of extracellular matrix in connective tissues.
C) ability of connective tissues to withstand mechanical stresses.
D) numerous connections that connective-tissue cells make with each other.

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An adult hemopoietic stem cell found in the bone marrow


A) will occasionally produce epidermal cells when necessary.
B) can produce only red blood cells.
C) can undergo self-renewing divisions for the lifetime of a healthy animal.
D) will express all the same transcription factors as those found in an unfertilized egg.

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Plasmodesmata


A) permit small molecules to pass from one cell to another.
B) are found only in animal cells.
C) are closed by the neurotransmitter dopamine.
D) provide tensile strength.

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Which of the following statements about tumor suppressor genes is FALSE?


A) Gene amplification of a tumor suppressor gene is less dangerous than gene amplification of a proto-oncogene.
B) Cells with one functional copy of a tumor suppressor gene will usually proliferate faster than normal cells.
C) Inactivation of tumor suppressor genes leads to enhanced cell survival and proliferation.
D) Individuals with only one functional copy of a tumor suppressor gene are more prone to cancer than individuals with two functional copies of a tumor suppressor gene.

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B

Which of the following statements about organoids is FALSE?


A) Organoids can be produced from ES and iPS cells.
B) Organoids can only be made for organs that are made up of a single type of differentiated cell.
C) Organoids are self-assembling.
D) Organoids can form multilayered structures.

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Match each name below with the best depiction of the type of epithelial sheet shown in Figure 20-2.Each name and each picture will only be used once. (A) Match each name below with the best depiction of the type of epithelial sheet shown in Figure 20-2.Each name and each picture will only be used once. (A)    (B)    (C)    (D)    Figure 20-2 -stratified __________ (B) Match each name below with the best depiction of the type of epithelial sheet shown in Figure 20-2.Each name and each picture will only be used once. (A)    (B)    (C)    (D)    Figure 20-2 -stratified __________ (C) Match each name below with the best depiction of the type of epithelial sheet shown in Figure 20-2.Each name and each picture will only be used once. (A)    (B)    (C)    (D)    Figure 20-2 -stratified __________ (D) Match each name below with the best depiction of the type of epithelial sheet shown in Figure 20-2.Each name and each picture will only be used once. (A)    (B)    (C)    (D)    Figure 20-2 -stratified __________ Figure 20-2 -stratified __________

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