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Refer to the following information to answer the questions below. A man who is an achondroplastic dwarf with normal vision marries a color-blind woman of normal height. The man's father was 6 feet tall, and both the woman's parents were of average height. Achondroplastic dwarfism is autosomal dominant, and red-green color blindness is X-linked recessive. -How many of their daughters might be expected to be color-blind dwarfs?


A) all
B) none
C) half
D) one out of four
E) three out of four

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How would one explain a testcross involving F₁ dihybrid flies in which more parental-type offspring than recombinant-type offspring are produced?


A) The two genes are closely linked on the same chromosome.
B) The two genes are linked but on different chromosomes.
C) Recombination did not occur in the cell during meiosis.
D) The testcross was improperly performed.
E) Both of the characters are controlled by more than one gene.

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Cinnabar eyes is a sex-linked recessive characteristic in fruit flies. If a female having cinnabar eyes is crossed with a wild-type male, what percentage of the F₁ males will have cinnabar eyes?


A) 0%
B) 25%
C) 50%
D) 75%
E) 100%

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Abnormal chromosomes are frequently found in malignant tumors. Errors such as translocations may place a gene in close proximity to different control regions. Which of the following might then occur to make the cancer worse?


A) an increase in nondisjunction
B) expression of inappropriate gene products
C) a decrease in mitotic frequency
D) death of the cancer cells in the tumor
E) sensitivity of the immune system

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What is a syndrome?


A) a characteristic facial appearance
B) a group of traits, all of which must be present if an aneuploidy is to be diagnosed
C) a group of traits typically found in conjunction with a particular chromosomal aberration or gene mutation
D) a characteristic trait usually given the discoverer's name
E) a characteristic that only appears in conjunction with one specific aneuploidy

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Calico cats are female because


A) the males die during embryonic development.
B) a male inherits only one of the two X-linked genes controlling hair color.
C) the Y chromosome has a gene blocking orange coloration.
D) only females can have Barr bodies.
E) multiple crossovers on the Y chromosome prevent orange pigment production.

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Males are more often affected by sex-linked traits than females because


A) male hormones such as testosterone often alter the effects of mutations on the X chromosome.
B) female hormones such as estrogen often compensate for the effects of mutations on the X chromosome.
C) X chromosomes in males generally have more mutations than X chromosomes in females.
D) males are hemizygous for the X chromosome.
E) mutations on the Y chromosome often worsen the effects of X-linked mutations.

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Which of the following two genes are closest on a genetic map of Drosophila?


A) b and vg
B) vg and cn
C) rb and cn
D) cn and b
E) b and rb

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Use the following information to answer the questions below. A plantlike organism on the planet Pandora can have three recessive genetic traits: bluish leaves, due to an allele (a) of gene A; a feathered stem, due to an allele (b) of gene B; and hollow roots due to an allele (c) of gene C. The three genes are linked and recombine as follows: A geneticist did a testcross with an organism that had been found to be heterozygous for the three recessive traits and she was able to identify progeny of the following phenotypic distribution (+ = wild type) : Use the following information to answer the questions below. A plantlike organism on the planet Pandora can have three recessive genetic traits: bluish leaves, due to an allele (a)  of gene A; a feathered stem, due to an allele (b)  of gene B; and hollow roots due to an allele (c)  of gene C. The three genes are linked and recombine as follows: A geneticist did a testcross with an organism that had been found to be heterozygous for the three recessive traits and she was able to identify progeny of the following phenotypic distribution (+ = wild type) :    -Which of the following are the phenotypes of the parents in this cross? A)  2 and 5 B)  1 and 6 C)  4 and 8 D)  3 and 7 E)  1 and 2 -Which of the following are the phenotypes of the parents in this cross?


A) 2 and 5
B) 1 and 6
C) 4 and 8
D) 3 and 7
E) 1 and 2

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Refer to the following information to answer the questions below. A man who is an achondroplastic dwarf with normal vision marries a color-blind woman of normal height. The man's father was 6 feet tall, and both the woman's parents were of average height. Achondroplastic dwarfism is autosomal dominant, and red-green color blindness is X-linked recessive. -They have a daughter who is a dwarf with normal color vision. What is the probability that she is heterozygous for both genes?


A) 0%
B) 25%
C) 50%
D) 75%
E) 100%

Correct Answer

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Which of the following is true of aneuploidies in general?


A) A monosomy is more frequent than a trisomy.
B) 45 X is the only known human live-born monosomy.
C) Some human aneuploidies have selective advantage in some environments.
D) Of all human aneuploidies, only Down syndrome is associated with mental retardation.
E) An aneuploidy resulting in the deletion of a chromosome segment is less serious than a duplication.

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A couple has a child with Down syndrome. The mother is 39 years old at the time of delivery. Which of the following is the most probable cause of the child's condition?


A) The woman inherited this tendency from her parents.
B) One member of the couple carried a translocation.
C) One member of the couple underwent nondisjunction in somatic cell production.
D) One member of the couple underwent nondisjunction in gamete production.
E) The mother had a chromosomal duplication.

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Suppose that a gene on human chromosome 18 can be imprinted in a given pattern in a female parent but not in a male parent. A couple in whom each maternal meiosis is followed by imprinting of this gene have children. What can we expect as a likely outcome?


A) All sons but no daughters will bear their mother's imprinting pattern.
B) All daughters but no sons will bear their mother's imprinting pattern.
C) All sons and daughters will have a 50% chance of receiving the mother's imprinting pattern.
D) All the children will bear their mother's imprinting pattern but only daughters will then pass it down.
E) Each of the children will imprint a different chromosome.

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Red-green color blindness is a sex-linked recessive trait in humans. Two people with normal color vision have a color-blind son. What are the genotypes of the parents?


A) XcXc and XcY
B) XcXc and XCY
C) XCXC and XcY
D) XCXC and XCY
E) XCXc and XCY

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Correns described that the inheritance of variegated color on the leaves of certain plants was determined by the maternal parent only. What phenomenon does this describe?


A) mitochondrial inheritance
B) chloroplast inheritance
C) genomic imprinting
D) infectious inheritance
E) sex-linkage

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Recombination between linked genes comes about for what reason?


A) Mutation on one homolog is different from that on the other homolog.
B) Independent assortment sometimes fails because Mendel had not calculated appropriately.
C) When genes are linked they always "travel" together at anaphase.
D) Crossovers between these genes result in chromosomal exchange.
E) Nonrecombinant chromosomes break and then re-join with one another.

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Why does recombination between linked genes continue to occur?


A) Recombination is a requirement for independent assortment.
B) Recombination must occur or genes will not assort independently.
C) New allele combinations are acted upon by natural selection.
D) The forces on the cell during meiosis II always result in recombination.
E) Without recombination there would be an insufficient number of gametes.

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Of the following human aneuploidies, which is the one that generally has the most severe impact on the health of the individual?


A) 47, +21
B) 47, XXY
C) 47, XXX
D) 47, XYY
E) 45, X

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In cats, black fur color is caused by an X-linked allele; the other allele at this locus causes orange color. The heterozygote is tortoiseshell. What kinds of offspring would you expect from the cross of a black female and an orange male?


A) tortoiseshell females; tortoiseshell males
B) black females; orange males
C) orange females; orange males
D) tortoiseshell females; black males
E) orange females; black males

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A woman is found to have 47 chromosomes, including three X chromosomes. Which of the following describes her expected phenotype?


A) masculine characteristics such as facial hair
B) enlarged genital structures
C) excessive emotional instability
D) normal female
E) sterile female

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