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What is usually required for B cell activation by an antigen?


A) other B cells
B) T cells
C) platelets
D) megakaryocytes
E) erythrocytes

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What is the physical sign that a person's immune system is involved in the proliferation of T cells in response to an infection?


A) The skin is reddened.
B) The lymph nodes in the region of the infection become enlarged.
C) The skin is bruised in the infected region.
D) The lymph nodes shrink because they are secreting so much material.
E) The temperature of the infected region decreases.

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The modified,harmless version of the tetanus toxin that is used to immunize infants is called a(n) _______.


A) toxin
B) poison
C) toxoid
D) toxico
E) toxon

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Which cells are characterized by their possession of CD4 and CD25 surface markers?


A) TH1 cells
B) TH2 cells
C) cytotoxic T lymphocytes
D) B cells
E) regulatory T lymphocytes

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The heavy chains of which class of antibody bind specifically to macrophage and neutrophil surface receptors,inducing these phagocytes to ingest the particle to which the antibodies are bound?


A) IgM
B) IgG
C) IgE
D) IgD
E) IgA

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What is found on the surface of T cells?


A) T cell receptors that allow a specific interaction with a particular antigen
B) B cells receptors that allow a specific interaction with a particular antigen
C) T cell antigens that allow a specific interaction with a particular antigen
D) B cell antigens that allow a specific interaction with a particular antigen
E) platelet receptors that allow a specific interaction with a particular antigen

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In some cases,the light chains of autoreactive antibodies can be replaced by a new light chain encoded by an immunoglobulin gene that has been secondarily rearranged in a process called _________.


A) receptor rearrangement
B) receptor editing
C) receptor stimulation
D) receptor costimulation
E) receptor subtraction

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The heavy chains of which class of antibody bind and activate one of the complement system proteins,leading to the lysis of the bacterial cell to which the antibody molecules are bound?


A) IgM
B) IgG
C) IgE
D) IgD
E) IgA

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Receptors on the surface of phagocytes that recognize certain types of highly conserved molecules that play essential roles in viruses and bacteria are called _______.


A) pattern recognition receptors
B) PRRs
C) Toll-like receptors
D) TLRs
E) All of these are correct.

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_________ occurs when a specific antibody changes the heavy chain that the cell makes without changing the antigen-combining site of the antibodies synthesized.


A) Class consistency
B) Somatic hypermutation
C) Class switching
D) Class hypermutation
E) Somatic switching

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Where do dendritic cells go once they have processed antigens and what do they do when they get there?


A) They go to the lymph nodes,where they undergo apoptosis.
B) They go to the liver,where they undergo apoptosis.
C) They go to the lymph nodes,where they differentiate into mature antigen-processing cells.
D) They go to the liver,where they differentiate into mature antigen-processing cells.
E) They go to the liver,where they proliferate.

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Who realized that a cowpox infection at an early age protected people against deadly smallpox infections? He had noticed that milkmaids were typically spared the ravages of smallpox.He turned this observation into vaccination by intentionally exposing a boy to cowpox to develop immunity and then later exposing the same boy to smallpox,which he survived.


A) Gregor Mendel
B) Caitlyn Jenner
C) Edward Jenner
D) Claude Bernard
E) Louis Pasteur

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Which of the following plays an important role in allergic reactions by binding to mast cell surfaces and what does that binding trigger?


A) IgE heavy chains,the release of histamine
B) IgE heavy chains,the release of allergan
C) IgE light chains,the uptake of histamine
D) IgE light chains,the release of allergan
E) IgA heavy chains,the release of histamine

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Which antibodies are the predominant antibodies in secretions of the respiratory,digestive and urogenital tracts?


A) IgGs
B) IgAs
C) IgMs
D) IgEs
E) IgDs

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Which antibodies have no clear function?


A) IgGs
B) IgAs
C) IgMs
D) IgEs
E) IgDs

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_________ are pathogens that are capable of stimulating immunity while being genetically crippled so that they are unable to cause disease.


A) Crippled pathogens
B) Weakened pathogens
C) Attenuated pathogens
D) Dystrophied pathogens
E) Disadvantaged pathogens

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In what way does the character of the antibodies made during a secondary response differ from those made during the primary response?


A) They are bigger.
B) They are smaller.
C) The antibodies of the secondary response have a much greater affinity for their antigen.
D) The antibodies of the secondary response have a much lower affinity for their antigen.
E) They are more stable.

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What holds the small peptide fragments of an antigen at the surface of an APC?


A) phosphotyrosine motifs
B) MHC proteins
C) T-cell receptors
D) phosphatidylinositol
E) B-cell receptors

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What determines the specificity of an antibody?


A) the amino acids of the antigen-combining sites at the ends of each arm of the Y-shaped antibody
B) the amino acids of the antigen-combining sites at the base of the Y-shaped antibody
C) the nucleic acids of the antigen-combining sites at the base of the Y-shaped antibody
D) the nucleic acids of the antigen-combining sites at the ends of each arm of the Y-shaped antibody
E) the amino acids of the antigen-combining sites at the end of one arm of the Y-shaped antibody

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MHC class II proteins are synthesized _____________.


A) as RER membrane proteins
B) as RER lumen proteins
C) as lysosomal membrane proteins
D) as lysosomal lumen proteins
E) as mitochondrial membrane proteins

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